GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE174nnn/GSE174160/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174160GEOGSEfalseSFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cellsHere, we investigated the role of SFPQ in the regulation of expression and function of F508del-CFTR in CF lung epithelial cells. We find that the expression of SFPQ is reduced in F508del-CFTR CF epithelial cells compared to WT-CFTR control cells. Interestingly, the overexpression of SFPQ in CF cells increases the expression as well as rescues the function of F508del­CFTR. Further, comprehensive transcriptome analyses indicate that SFPQ plays a key role in activating the mutant F508del-CFTR by modulating several cellular signaling pathways. This is the first report on the role of SFPQ in the regulation of expression and function of F508del-CFTR in CF lung disease.2026/04/21GSE174160GSM5288125GSM5288126GSM5288130GSM5288127GSM5288128GSM528812916791SRP319174174160Homo sapiens[34404863]