GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE175nnn/GSE175693/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE175693GEOGSEfalseMapping the effects of plasma-mediated rejuvenation across brain regionsSystemic factors found in plasma of young mice and humans impact cognition and can functionally rejuvenate the aging brain. However, scalable, molecular tools to profile this process are currently missing, hampering efforts to translate these findings into clinical applications. Here, we leverage the advents of brain-region-specific transcriptomics as a readout of cellular deterioration accompanying the aging process. Profiling expression shifts in cortex (Cor), hippocampus (Hip) and Cerebellum (Ceb) we identify the region-specific responses to young plasma. This atlas of brain rejuvenation supports the identification of potential mediators of plasma-derived factors, and provides the basis for finding a minimal gene expression set - a signature - to sufficiently quantify brain rejuvenation.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 musculus