GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE17nnn/GSE17757/primaryOK2000000Genomics Homo sapiensMacaca mulattaExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE17757GEOGSE0falseGene expression data from primate postnatal brain in prefrontal cortex: time courseGene expression changes determine functional differentiation during development and are associated with functional decline during aging. While developmental changes are tightly regulated, regulation of aging changes is not well established. To assess the regulatory basis of age-related changes and investigate the mechanism of regulatory transition between development and aging, we measured mRNA and microRNA expression patterns in brains (superior frontal gyrus) of humans and rhesus macaques over the entire species’ lifespan. We find that in both species, developmental and aging changes overlap in the course of lifetime with many changes found at the late age initiating in early childhood.2010/06/10GSE17757GSM443497GSM443498GSM443499GSM443523GSM443524GSM443525GSM443486GSM443487GSM443520GSM443521GSM443488GSM443489GSM443522GSM443493GSM443494GSM443495GSM443496GSM443490GSM443491GSM443492GSM443516GSM443517GSM443518GSM443519GSM443512GSM443479GSM443513GSM443514GSM443515GSM443475GSM443476GSM443510GSM443477GSM443478GSM443511GSM443482GSM443483GSM443484GSM443485GSM443480GSM443481GSM443509GSM443505GSM443506GSM443507GSM443508GSM443501GSM443502GSM443503GSM443504GSM443500624417757 Homo sapiensMacaca mulatta[28724976][20647238]