GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE18nnn/GSE18012/primaryOK2000000GenomicsHomo sapiensNon-coding RNA profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE18012GEOGSE0falsemiRNA expression data from human postnatal brain in prefrontal cortex: time courseGene expression changes determine functional differentiation during development and are associated with functional decline during aging. While developmental changes are tightly regulated, regulation of aging changes is not well established. To assess the regulatory basis of age-related changes and investigate the mechanism of regulatory transition between development and aging, we measured mRNA and microRNA expression patterns in brains of humans and rhesus macaques over the entire species’ lifespan. We find that in both species, developmental and aging changes overlap in the course of lifetime with many changes found at the late age initiating in early childhood. Keywords: miRNA Age Series Keywords: Non-coding RNA profiling by high throughput sequencing2010/06/10GSE18012GSM450609GSM450608GSM450601GSM450600GSM450603GSM450602GSM450605GSM450604GSM450607GSM450606GSM450597GSM450599GSM450610GSM450598911518012Homo sapiens[28724976][20647238]