GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE18nnn/GSE18424/primaryOK2000000GenomicsSalmonella enterica Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344Expression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE18424GEOGSE0falseThe effect of stpA deletion on S. Typhimurium gene expression during growth in rich mediumStpA is a paralogue of the nucleoid associated protein H-NS that is conserved in a range of enteric bacteria and had no known function in Salmonella enterica serovar Typhimurium. Here, we show that 5% of the Salmonella genome is regulated by StpA, which contrasts with the situation in Escherichia coli where deletion of stpA only had minor effects on gene expression. The StpA-dependent genes of S. Typhimurium are a specific subset of the H-NS regulon that are predominantly under the positive control of sigma38 (RpoS), CRP-cAMP and PhoP. The regulatory role of StpA varied at different growth phases; StpA only controlled sigma38 levels at mid-exponential phase when it prevented inappropriate activation of sigma38 during rapid bacterial growth. In contrast, StpA only activated the CRP-cAMP regulon during late exponential phase.2009/10/28GSE18424GSM459246GSM459245GSM459105GSM459248GSM459247GSM459242GSM459241GSM459120GSM459244GSM459243GSM459240GSM459118GSM459239GSM459117GSM459119GSM459114GSM459113GSM459116GSM459115GSM459110GSM459112GSM459111GSM459271GSM459272GSM459107GSM459106GSM459109GSM4591085780909118424Salmonella enterica Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344[19843227]