{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE184nnn/GSE184258/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE184258"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic Analysis Reveals the Responses of Dendritic Cells to Vdbp","description":"Our current study overexpressed Vdbp stably in DC to explore the function of this gene. CKK-8 results revealed Vdbp successfully inhibited viability of DC. Besides, we found overexpressing this gene greatly promoted apoptosis and obviously altered cell cycle distribution in DC. Moreover, RNA sequencing (RNA-seq) was carried out and numerous differently expressed genes (DEGs) were obtained. The results indicated that Vdbp globally mediated expression of mRNAs, which might translate into its potential functions. Finally, bio-informatics analysis illustrated that most DEGs were more uniformly enriched in immunity-related pathways. We believe that Vdbp regulates the function of DC by altering its cellular immunity.","dates":{"publication":"2024/07/31"},"accession":"GSE184258","cross_references":{"GSM":["GSM5582627","GSM5582628","GSM5582629","GSM5582630","GSM5582631","GSM5582626"],"GPL":["24247"],"SRA":["SRP337400"],"GSE":["184258"],"taxon":["Mus musculus"]}}