GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE184nnn/GSE184258/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE184258GEOGSEfalseTranscriptomic Analysis Reveals the Responses of Dendritic Cells to VdbpOur current study overexpressed Vdbp stably in DC to explore the function of this gene. CKK-8 results revealed Vdbp successfully inhibited viability of DC. Besides, we found overexpressing this gene greatly promoted apoptosis and obviously altered cell cycle distribution in DC. Moreover, RNA sequencing (RNA-seq) was carried out and numerous differently expressed genes (DEGs) were obtained. The results indicated that Vdbp globally mediated expression of mRNAs, which might translate into its potential functions. Finally, bio-informatics analysis illustrated that most DEGs were more uniformly enriched in immunity-related pathways. We believe that Vdbp regulates the function of DC by altering its cellular immunity.2024/07/31GSE184258GSM5582627GSM5582628GSM5582629GSM5582630GSM5582631GSM558262624247SRP337400184258Mus musculus