GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE184nnn/GSE184956/primaryOK200GenomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE184956GEOGSEfalseComparative transcriptome analysis in monocyte-derived macrophages of asymptomatic GBA mutation carriers and patients with GBA-associated Parkinson’s diseaseWe compared transcriptome of monocyte-derived macrophages of 5 patients with GBA-PD (4 L444P/N, 1 N370S/N) and 4 asymptomatic GBA mutation carriers (GBA-carriers) (3 L444P/N, 1 N370S/N) and 4 controls. We also conducted comparative transcriptome analysis for L444P/N only GBA-PD patients and GBA-carriers. Revealed deregulated genes in GBA-PD independently of GBA mutations (L444P or N370S) were involved in immune response, neuronal function. We found upregulated pathway associated with zinc metabolism in L444P/N GBA-PD patients. The potential important role of DUSP1 in the pathogenesis of GBA-PD was suggested.2021/09/29GSE184956GSM5602426GSM5602437GSM5602427GSM5602428GSM5602429GSM5602433GSM5602434GSM5602435GSM5602425GSM5602436GSM5602430GSM5602431GSM560243218460SRP339169184956Homo sapiens[34680941]