GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE189nnn/GSE189489/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE189489GEOGSEfalseRNAseq data of mouse B16-F10 melanoma cell lines after siEzh2 knockdown or GSK126 methyl-transferase inhibitor or DZNep treatmentEnhancer of zeste homolog 2 (EZH2) plays critical roles in the progression of many malignancies including melanoma. The most well-known EZH2 mechanism is regulating gene expression through catalysing tri-methylation of histone H3 at Lys 27 (H3K27me3). However, EZH2 also have methylation-independent activities that limit the therapeutic potential of EZH2 methyl-transferase inhibitors. To investigate the methyl-transferase independent role of EZH2 in melanoma, we performed global gene expression analysis of B16-F10 cells treated with methyl-transferase inhibitor GSK126 or siEzh2 knockdown or the EZH2 degrader DZNep.2026/07/02GSE189489GSM5702493GSM5702492GSM5702495GSM5702484GSM5702494GSM5702486GSM5702485GSM5702488GSM5702487GSM5702491GSM5702490GSM5726839GSM5726838GSM5726837GSM570248913112SRP347616189489Mus musculus