{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE199nnn/GSE199064/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":[" Genome binding/occupancy profiling by high throughput sequencing","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE199064"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single cell multiomic landscape reveals gene programs driving lipid droplet heterogeneity in hepatic steatosis","description":"Alcohol-associated liver disease (ALD) in its earliest form is evidenced as hepatic steatosis which may progress to liver cirrhosis. Using single-cell multiomics technology, we studied transcriptional mechanisms across the hepatic lobule that could account for liver zonation of lipid droplets in a murine ALD model. Furthermore, chromatin landscape studies demonstrated zonation of regulatory elements and master transcription factors associated with these changes in the transcriptome.","dates":{"publication":"2026/04/01"},"accession":"GSE199064","cross_references":{"GSM":["GSM5963648","GSM5963649","GSM5963650","GSM5963651"],"GPL":["21103"],"GSE":["199064"],"taxon":["Mus musculus"],"PMID":["[41730984]"]}}