{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE199nnn/GSE199995/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE199995"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA expression data from fibroblasts, iPSCs, iNPCs and iDopaminergicNeurons (Williams Beuren Syndrome, 7q11.23 microduplicatino Syndrome, controls)","description":"7q11.23 microduplication syndrome (DUP7) and Williams-Beuren syndrome (WBS) are rare multisystemic disorders with somehow opposed neurobehavioural trajectories caused by 1.55-1.83 Mb heterozygous microduplication or microdeletion of ~30 contiguous genes at 7q11.23, respectively. Cellular reprogramming is a good approach to overcome the experimental limitations to study neurodevelopmental disorders in humans. The purpose of this project is to evaluate the transcriptomic consequences of 7q11.23 patient-derived iPSC lines and neuronal derivatives. We differentiated patient-specific iPSCs generated from fibroblasts from four DUP7 patients, four WBS patients and two controls, to neural progenitor cells (iNPCs) and to dopaminergic neurons (iNeus). We assessed genome-wide differential expression using expression microarrays in all cell types","dates":{"publication":"2026/05/07"},"accession":"GSE199995","cross_references":{"GSM":["GSM6001599","GSM6001598","GSM6001595","GSM6001594","GSM6001597","GSM6001596","GSM6001591","GSM6001590","GSM6001593","GSM6001592","GSM6001588","GSM6001621","GSM6001620","GSM6001587","GSM6001623","GSM6001589","GSM6001622","GSM6001584","GSM6001583","GSM6001586","GSM6001585","GSM6001580","GSM6001582","GSM6001581","GSM6001618","GSM6001617","GSM6001619","GSM6001614","GSM6001613","GSM6001616","GSM6001615","GSM6001577","GSM6001610","GSM6001576","GSM6001612","GSM6001579","GSM6001611","GSM6001578","GSM6001573","GSM6001572","GSM6001575","GSM6001574","GSM6001571","GSM6001570","GSM6001607","GSM6001606","GSM6001609","GSM6001608","GSM6001603","GSM6001569","GSM6001602","GSM6001605","GSM6001604","GSM6001566","GSM6001565","GSM6001568","GSM6001601","GSM6001600","GSM6001567"],"GPL":["16686"],"GSE":["199995"],"taxon":["Homo sapiens"]}}