GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE199nnn/GSE199995/primaryOK200TranscriptomicsHomo sapiensExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE199995GEOGSEfalseRNA expression data from fibroblasts, iPSCs, iNPCs and iDopaminergicNeurons (Williams Beuren Syndrome, 7q11.23 microduplicatino Syndrome, controls)7q11.23 microduplication syndrome (DUP7) and Williams-Beuren syndrome (WBS) are rare multisystemic disorders with somehow opposed neurobehavioural trajectories caused by 1.55-1.83 Mb heterozygous microduplication or microdeletion of ~30 contiguous genes at 7q11.23, respectively. Cellular reprogramming is a good approach to overcome the experimental limitations to study neurodevelopmental disorders in humans. The purpose of this project is to evaluate the transcriptomic consequences of 7q11.23 patient-derived iPSC lines and neuronal derivatives. We differentiated patient-specific iPSCs generated from fibroblasts from four DUP7 patients, four WBS patients and two controls, to neural progenitor cells (iNPCs) and to dopaminergic neurons (iNeus). We assessed genome-wide differential expression using expression microarrays in all cell types2026/05/07GSE199995GSM6001599GSM6001598GSM6001595GSM6001594GSM6001597GSM6001596GSM6001591GSM6001590GSM6001593GSM6001592GSM6001588GSM6001621GSM6001620GSM6001587GSM6001623GSM6001589GSM6001622GSM6001584GSM6001583GSM6001586GSM6001585GSM6001580GSM6001582GSM6001581GSM6001618GSM6001617GSM6001619GSM6001614GSM6001613GSM6001616GSM6001615GSM6001577GSM6001610GSM6001576GSM6001612GSM6001579GSM6001611GSM6001578GSM6001573GSM6001572GSM6001575GSM6001574GSM6001571GSM6001570GSM6001607GSM6001606GSM6001609GSM6001608GSM6001603GSM6001569GSM6001602GSM6001605GSM6001604GSM6001566GSM6001565GSM6001568GSM6001601GSM6001600GSM600156716686199995Homo sapiens