{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE202nnn/GSE202816/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE202816"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Homeostatic inflammation in the placenta is protective against adult cardiovascular and depressive outcomes ","description":"Pathological placental inflammation is associated with an increased risk of several adult disorders. However, many inflammation related genes are highly expressed in the healthy placenta. Their contribution to adult health outcomes in this context is unknown but may inform mechanisms of risk associated with pathological placental inflammation. We studied this using RNA sequencing and weighted correlation network analysis in 42 healthy, term placental samples from the GUSTO study. We identified a module strongly associated with homeostatic inflammation and highly enriched in Hofbauer cells. By leveraging placental expression quantitative trait loci (eQTLs), we generated a polygenic score (PGS) that specifically predicted expression of this module in GUSTO. Using identical criteria, we created a PGS in the UK Biobank and carried out a phenome wide association study of 1831 traits. This produced 21 associations (FDR<0.05) primarily within the cardiovascular and mental health domains. Further regression and mendelian randomization analyses identified sex-dependent protective effects on cardiovascular and depressive outcomes. We demonstrate that genes differentially regulated by intra-amniotic infection are both highly enriched and highly connected within our module, suggesting severe module disruption during prenatal infection. This suggests prenatal infection, at least partially confers, risk for adult cardiovascular and depressive outcomes through disrupting protective homeostatic inflammatory expression patterns in the placenta. We finally identify Aspirin as a therapeutic target to mitigate these effects.  ","dates":{"publication":"2026/05/18"},"accession":"GSE202816","cross_references":{"GSM":["GSM6133779","GSM6133778","GSM6133797","GSM6133775","GSM6133774","GSM6133796","GSM6133777","GSM6133799","GSM6133798","GSM6133776","GSM6133771","GSM6133793","GSM6133792","GSM6133770","GSM6133795","GSM6133773","GSM6133794","GSM6133772","GSM6133791","GSM6133790","GSM6133805","GSM6133804","GSM6133807","GSM6133806","GSM6133768","GSM6133801","GSM6133800","GSM6133789","GSM6133767","GSM6133803","GSM6133769","GSM6133802","GSM6133786","GSM6133764","GSM6133763","GSM6133785","GSM6133788","GSM6133766","GSM6133787","GSM6133765","GSM6133782","GSM6133781","GSM6133784","GSM6133783","GSM6133780"],"GPL":["11154"],"GSE":["202816"],"taxon":["Homo sapiens"]}}