GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE20nnn/GSE20588/primaryOK2000000GenomicsMus musculusExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE20588GEOGSE0falseEffect of rosiglitazone on adipose gene expression in HSL knockout mice with different diet treatmentTo test whether HSL is required for the supply of intrinsic ligands for PPARg for normal adipose differentiation, HSL-/- and wild type (WT) littermates were fed normal chow (NC) and high fat (HF) diets supplemented with or without rosiglitazone (200 mg/kg) for 16 weeks. The expression of diabetes related genes in the WAT of the animals was analyzed using Oligo GEArray Mouse Diabetes Microarrays (OMM-023, SABiosciences, Frederick, MD). Together with other biochemical and physiological data, our results suggest that one of the mechanisms by which HSL modulates adipose metabolism is by providing intrinsic ligands for PPARg.2012/03/18GSE20588GSM517113GSM517112GSM517134GSM517115GSM517114GSM517117GSM517116GSM517119GSM517118GSM517131GSM517130GSM517133GSM517111GSM517132GSM517110GSM517109GSM517124GSM517123GSM517104GSM517126GSM517125GSM517103GSM517128GSM517106GSM517127GSM517105GSM517108GSM517107GSM517129GSM517120GSM517122GSM5171211012120588Mus musculus