{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE215nnn/GSE215923/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":[" Genome binding/occupancy profiling by high throughput sequencing","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE215923"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Hematopoietic stem cell sex-dimorphism intensifies aging phenotypes and downstream hematopoiesis","description":"Hematopoietic stem cells (HSCs) sustain blood and immune production throughout life and are central to aging and disease. Yet, most studies of HSC aging rely on male mice, leaving sex-specific trajectories poorly defined. We profiled HSC aging across the lifespan in male and female mice using multi-omic analyses and over 820 animals. Two patterns emerged. In males, HSCs continue to remodel after mid-life, showing progressive accumulation of CD150^high myeloid-biased cells, widespread transcriptional shifts, and chromatin reprogramming. In females, HSC changes plateau earlier but exhibit greater inter-individual variability. Integration of RNA-seq, ATAC-seq, and single-cell data implies GATA, RUNX, and Sema4a as key factors. Surprisingly, transplantation studies revealed that many sex-dependent phenotypes are overridden by the host environment. These findings define distinct, sex-specific trajectories of hematopoietic aging and provide a comprehensive resource to guide mechanistic studies and inform sex-tailored therapeutic strategies.","dates":{"publication":"2026/09/09"},"accession":"GSE215923","cross_references":{"GSM":["GSM9229211","GSM9229210","GSM9229199","GSM9229213","GSM9229212","GSM9229215","GSM9229214","GSM9229192","GSM9229191","GSM9229194","GSM9229193","GSM9229196","GSM9229195","GSM9229198","GSM9229197","GSM6647496","GSM6647495","GSM6647497","GSM6647492","GSM6647494","GSM9229190","GSM6647493","GSM9229208","GSM9229207","GSM9229209","GSM9229200","GSM9229202","GSM9229201","GSM9229204","GSM9229203","GSM9229206","GSM9229205"],"GPL":["17021","24247"],"GSE":["215923"],"taxon":["Mus musculus"],"PMID":["[42618695]"]}}