GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE21nnn/GSE21986/primaryOK2000000GenomicsHomo sapiensGenome variation profiling by genome tiling arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE21986GEOGSE0falseGenomic profiling of Imatinib resistance in CD34+ cell populations from chronic myeloid leukaemia patients using Agilent-014698 Whole Human Genome 105K microarrays.To ascertain genomic alterations associated with Imatinib resistance in chronic myeloid leukaemia, we performed high resolution genomic analysis of CD34+ cells from 25 Imatinib (IM) resistant and 11 responders CML patients. Using patients' T-cells as reference, we found significant association between number of acquired cryptic copy number alterations (CNA) and disease phase (p=0.036) or loss of IM response for patients diagnosed in chronic phase (CP) (p=0.04). Recurrent cryptic losses were identified on chromosomes 7, 12 and 13. On chromosome 7, recurrent deletions of the IKZF1 locus were detected, for the first time, in four patients in CP.2010/11/15GSE21986GSM546834GSM546812GSM546833GSM546811GSM546799GSM546810GSM546832GSM546798GSM546831GSM546838GSM546816GSM546815GSM546837GSM546836GSM546814GSM546813GSM546835GSM546818GSM546817GSM546801GSM546800GSM546827GSM546805GSM546804GSM546826GSM546825GSM546803GSM546824GSM546802GSM546809GSM546808GSM546807GSM546829GSM546828GSM546806GSM546830907521986Homo sapiens[20684991]