{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE225nnn/GSE225862/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Non-coding RNA profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE225862"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Endothelin-1 overexpression in mice increases vascular Vegfa164 and Vegfa188 alternative splice isoforms via enhanced Khdrbs3 expression","description":"Transgenic mice with tamoxifen-inducible endothelium-restricted human endothelin-1 overexpression (ieET-1) exhibited blood pressure (BP) elevation after 3 weeks and 3 months induction. Vascular injury was observed only after a 3-month exposure to human ET-1 overexpression. It is unknown whether 3-week or 3-month exposure to ET-1 overexpression results in gene dysregulation. We aimed to identify differentially expressed (DE) microRNAs and total RNA in mesenteric arteries of ieET-1 mice after 3-week and 3-month induction of human ET-1 overexpression.","dates":{"publication":"2026/05/15"},"accession":"GSE225862","cross_references":{"GSM":["GSM7058839","GSM7058838","GSM7058846","GSM7058845","GSM7058848","GSM7058847","GSM7058842","GSM7058841","GSM7058863","GSM7058844","GSM7058843","GSM7058860","GSM7058862","GSM7058840","GSM7058861","GSM7058849","GSM7058835","GSM7058857","GSM7058856","GSM7058834","GSM7058859","GSM7058837","GSM7058858","GSM7058836","GSM7058853","GSM7058852","GSM7058855","GSM7058833","GSM7058832","GSM7058854","GSM7058851","GSM7058850"],"GPL":["17021"],"GSE":["225862"],"taxon":["Mus musculus"],"PMID":["[42253124]"]}}