{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE225nnn/GSE225866/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE225866"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Endothelin-1 overexpression in mice increases vascular Vegfa164 and Vegfa188 alternative splice isoforms via enhanced Khdrbs3 expression","description":"Transgenic mice with tamoxifen-inducible endothelium-restricted human endothelin-1 overexpression (ieET-1) exhibited blood pressure (BP) elevation after 3 weeks and 3 months induction. Vascular injury was observed only after a 3-month exposure to human ET-1 overexpression. It is unknown whether 3-week or 3-month exposure to ET-1 overexpression results in gene dysregulation. We aimed to identify differentially expressed (DE) microRNAs and total RNA in mesenteric arteries of ieET-1 mice after 3-week and 3-month induction of human ET-1 overexpression.","dates":{"publication":"2026/05/15"},"accession":"GSE225866","cross_references":{"GSM":["GSM7058908","GSM7058905","GSM7058904","GSM7058907","GSM7058906","GSM7058901","GSM7058900","GSM7058889","GSM7058903","GSM7058902","GSM7058897","GSM7058886","GSM7058896","GSM7058885","GSM7058888","GSM7058899","GSM7058898","GSM7058887","GSM7058893","GSM7058892","GSM7058895","GSM7058894","GSM7058891","GSM7058890"],"GPL":["17021"],"GSE":["225866"],"taxon":["Mus musculus"],"PMID":["[42253124]"]}}