{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE229nnn/GSE229384/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE229384"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Non-severe thermal burn injuries induce long lasting gene expression changes in specific cortical neuron and glia cell types","description":"Burn injuries are devastating traumas, often leading to life-long consequences that extend beyond the observable burn scar. Burn injury patients commonly develop chronic neurological disorders but the long-lasting impacts of burn injuries on neurons and glia in the brain is unknown. Whole transcriptome RNA-sequencing from cortical excitatory neurons, inhibitory neurons, astrocytes and microglia showed very few changes to the expression of genes with known functions five weeks following a non-severe burn injury in adult mice. However, genes related to GABA-A receptors in excitatory neurons and several cellular functions in microglia was found to be to differentially expressed in burn injured mice. These findings shed light on the long-term effect of burn injuries on the brain and may help identify potential therapeutic targets and windows to prevent neurological dysfunction in burn patients.","dates":{"publication":"2024/02/15"},"accession":"GSE229384","cross_references":{"GSM":["GSM7161238","GSM7161237","GSM7161245","GSM7161288","GSM7161244","GSM7161247","GSM7161285","GSM7161241","GSM7161240","GSM7161284","GSM7161243","GSM7161242","GSM7161286","GSM7161281","GSM7161280","GSM7161283","GSM7161227","GSM7161226","GSM7161229","GSM7161228","GSM7161234","GSM7161278","GSM7161277","GSM7161233","GSM7161236","GSM7161279","GSM7161235","GSM7161274","GSM7161230","GSM7161273","GSM7161232","GSM7161275","GSM7161272","GSM7161271","GSM7161219","GSM7161216","GSM7161259","GSM7161215","GSM7161218","GSM7161223","GSM7161267","GSM7161222","GSM7161266","GSM7161225","GSM7161269","GSM7161268","GSM7161262","GSM7161265","GSM7161221","GSM7161220","GSM7161264","GSM7161261","GSM7161260","GSM7161249","GSM7161248","GSM7161255","GSM7161214","GSM7161258","GSM7161257","GSM7161251","GSM7161254","GSM7161253","GSM7161250"],"GPL":["24247"],"GSE":["229384"],"taxon":["Mus musculus"],"PMID":["[38476460]"]}}