{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE233nnn/GSE233725/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE233725"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effect of RNF4 depletion on GSK3685032-induced chromatin accessibilty changes in MV4-11 cells [ATAC-seq]","description":"GSK3685032-induced DNA hypomethylation results in upregulation of largely viral-responsive gene expression pathways and cell death. We identified that loss of RNF4 causes resistance to GSK3685032. We established RNF4 wild type and deficient MV4-11 cells by CRISPR-Cas9 disruption and treated with vehicle or GSK3685032 to determine how RNF4-deficiency impacts GSK3685032-induced gene expression changes","dates":{"publication":"2026/05/17"},"accession":"GSE233725","cross_references":{"GSM":["GSM7433275","GSM7433276","GSM7433273","GSM7433274","GSM7433279","GSM7433277","GSM7433278","GSM7433271","GSM7433272","GSM7433280","GSM7433281"],"GPL":["24676"],"GSE":["233725"],"taxon":["Homo sapiens"]}}