{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE235512"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Gene expression profile at the single-cell level of skin and PBMC samples collected from patients with severe cutaneous adverse drug reactions (SCADR).","description":"Severe cutaneous adverse drug reactions (SCADR) encompass a wide spectrum of potentially dreadful disease entities resulting from a type IV delayed hypersensitivity reaction. Single-cell RNA sequencing (scRNA-seq) provides an opportunity to decipher potential cell-cell interactions and cell-type specific transcriptomic changes, amenable to therapeutic intervention, particularly in rare diseases with heterogenous clinical presentations and lacking experimental animal models, such as SCADR. We performed scRNA-seq on the skin of four patients diagnosed with SCADR syndromes including one toxic epidermal necrolysis (TEN), one Stevens-Johnson syndrome (SJS), one acute generalized exanthematous pustulosis (AGEP), and one extensive drug-related maculopapular rash (MPR), and three healthy controls.","dates":{"publication":"2026/06/01"},"accession":"GSE235512","cross_references":{"GSM":["GSM7504440","GSM7504450","GSM7504442","GSM7504441","GSM7504448","GSM7504437","GSM7504447","GSM7504439","GSM7504449","GSM7504438","GSM7504444","GSM7504443","GSM7504446","GSM7504445"],"GPL":["20301"],"GSE":["235512"],"taxon":["Homo sapiens"]}}