GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE235nnn/GSE235593/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE235593GEOGSEfalseImpact of Conditional Knockout of Complement C3 and Sphingosine-1-Phosphate Receptor 1 (S1PR1) on Lung Metastasis in MMTV-PyMT MiceRecent evidence suggests that sphingosine-1-phosphate receptor 1 (S1PR1) modulates the intracellular complement system or the complosome to induce NLRP3 inflammasome formation and the release of IL-1β through caspase-1, thereby promoting tumor metastasis. Here, we examined the transcriptomic effects of S1PR1 and complement C3 conditional knockouts on lung metastasis in MMTV-PyMT Mice, a widely used model for studying mammary tumor progression and metastasis.2026/06/19GSE235593GSM7506003GSM7506004GSM7506001GSM7506002GSM7506000GSM7505999GSM7505998GSM7506009GSM7506007GSM7506008GSM7506005GSM750600624247235593Mus musculus