{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE235nnn/GSE235686/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE235686"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Acute Myeloid Leukemia patient/ CD34+ healthy donor RNA-seq","description":"AML is an aggressive and heterogenous hematologic malignancy. Here, we performed bulk RNA sequencing of 16 AML patients and primary hematopoietic cell populations, CD34+ HSC and CD14+monocytes to understand transcriptional and post-transcriptional mechanisms that drive leukemogenesis and block AML differentiation. Our findings provide a better understanding of gene regulatory pathways in AML in comparison to normal hematopoietic cells, which may provide new therapeutic strategy to selectively target AML cells.","dates":{"publication":"2026/06/01"},"accession":"GSE235686","cross_references":{"GSM":["GSM7507895","GSM7507896","GSM7507893","GSM7507894","GSM7507891","GSM7507892","GSM7507890","GSM7507903","GSM7507904","GSM7507901","GSM7507902","GSM7507899","GSM7507888","GSM7507900","GSM7507889","GSM7507897","GSM7507898"],"GPL":["24676"],"GSE":["235686"],"taxon":["Homo sapiens"]}}