{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE237nnn/GSE237027/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE237027"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic changes in Grin2b-C456Y-mutant mice with NMDAR activation","description":"Our previous study reported a Grin2b-mutant mouse line carrying a point mutation identified in individuals with ASD (Grin2b+/C456Y mice), which show suppressed long-term depression and anxiolytic-like behavior that are responsive to early chronic D-cycloserine (DCS) treatment (postnatal day 7 to 16) for pharmacological activation of NMDARs. To figure out the rescue mechanism, we attempted RNA-Seq analysis of wild-type (WT) and Grin2b+/C456Y mice that are early and chronically treated with vehicle and DCS.","dates":{"publication":"2026/07/09"},"accession":"GSE237027","cross_references":{"GSM":["GSM7593209","GSM7593219","GSM7593208","GSM7593218","GSM7593207","GSM7593213","GSM7593202","GSM7593212","GSM7593201","GSM7593200","GSM7593211","GSM7593210","GSM7593199","GSM7593217","GSM7593206","GSM7593216","GSM7593205","GSM7593215","GSM7593204","GSM7593214","GSM7593203","GSM7593198","GSM7593197"],"GPL":["24247"],"GSE":["237027"],"taxon":["Mus musculus"]}}