GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE237nnn/GSE237027/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE237027GEOGSEfalseTranscriptomic changes in Grin2b-C456Y-mutant mice with NMDAR activationOur previous study reported a Grin2b-mutant mouse line carrying a point mutation identified in individuals with ASD (Grin2b+/C456Y mice), which show suppressed long-term depression and anxiolytic-like behavior that are responsive to early chronic D-cycloserine (DCS) treatment (postnatal day 7 to 16) for pharmacological activation of NMDARs. To figure out the rescue mechanism, we attempted RNA-Seq analysis of wild-type (WT) and Grin2b+/C456Y mice that are early and chronically treated with vehicle and DCS.2026/07/09GSE237027GSM7593209GSM7593219GSM7593208GSM7593218GSM7593207GSM7593213GSM7593202GSM7593212GSM7593201GSM7593211GSM7593200GSM7593210GSM7593199GSM7593217GSM7593206GSM7593216GSM7593205GSM7593215GSM7593204GSM7593214GSM7593203GSM7593198GSM759319724247237027Mus musculus