{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE240nnn/GSE240024/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE240024"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"PI3K signaling is essential for leukemic transformation of Tet2 mutated pre-leukemic hematopoietic stem cells","description":"Inhibition of PI3K rescues Tet2 loss driven leukemia. The signaling pathways by which Tet2 mutations contribute to myeloid transformation are poorly understood. We investigated that loss of Tet2 in HSC/Ps results in myeloproliferation, which is associated with hyperactivation of the PI3Kinase pathway.","dates":{"publication":"2026/04/01"},"accession":"GSE240024","cross_references":{"GSM":["GSM7679988","GSM7679987","GSM7679986","GSM7679985","GSM7679984","GSM7679983","GSM7679982","GSM7679981","GSM7679980","GSM7679979","GSM7679978","GSM7679989"],"GPL":["21103"],"GSE":["240024"],"taxon":["Mus musculus"]}}