GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE240nnn/GSE240024/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE240024GEOGSEfalsePI3K signaling is essential for leukemic transformation of Tet2 mutated pre-leukemic hematopoietic stem cellsInhibition of PI3K rescues Tet2 loss driven leukemia. The signaling pathways by which Tet2 mutations contribute to myeloid transformation are poorly understood. We investigated that loss of Tet2 in HSC/Ps results in myeloproliferation, which is associated with hyperactivation of the PI3Kinase pathway.2026/04/01GSE240024GSM7679988GSM7679987GSM7679986GSM7679985GSM7679984GSM7679983GSM7679982GSM7679981GSM7679980GSM7679979GSM7679978GSM767998921103240024Mus musculus