{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE244nnn/GSE244163/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE244163"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Multi-platform genomic analysis of matched well- and dedifferentiated liposarcomas identify novel risk and progression determinants","description":"To define mechanisms that regulate biological behavior in well- and dedifferentiated liposarcoma (WD/DDLS) subsets, we describe an integrative analysis of DNA sequence, copy number and gene expression in 9 paired WDLS and DDLS samples with validation cohorts and in vitro studies. Amplification of 12q13-15 was common to all WDLS; 6q23-25 amplifications were observed 18% of WDLS and were associated with increased TAB2 and higher local recurrence risk versus non-6q-amplified WDLS. TAB2 knockdown decreased MDM2 protein expression and induced markers of cellular senescence in 6q23-25-amplified WDLS cells but not in non-amplified WDLS of amplified DDLS cells. Amplification of 6q23-25 was not associated with DDLS recurrence risk or progression from WDLS to DDLS. Instead, pathogenic ATRX mutations, recurrent losses in 13q and gains in 8q12-21 accompanied dedifferentiation. Downregulation of the 13q-encoded genes MYCBP2 and IRS2 was observed in DDLS versus WDLS; in vitro, these genes were essential for WDLS cell differentiation. Taken together, this study defines a copy number-driven model of liposarcoma initiation, progression, and differentiation.","dates":{"publication":"2026/08/04"},"accession":"GSE244163","cross_references":{"GSM":["GSM7808139","GSM7808018","GSM7808017","GSM7808138","GSM7808019","GSM7808014","GSM7808135","GSM7808013","GSM7808134","GSM7808016","GSM7808137","GSM7808015","GSM7808136","GSM7808098","GSM7808010","GSM7808131","GSM7808130","GSM7808097","GSM7808133","GSM7808012","GSM7808099","GSM7808132","GSM7808011","GSM7808094","GSM7808093","GSM7808096","GSM7808095","GSM7808029","GSM7808028","GSM7808149","GSM7808025","GSM7808146","GSM7808024","GSM7808145","GSM7808027","GSM7808148","GSM7808147","GSM7808026","GSM7808142","GSM7808021","GSM7808141","GSM7808020","GSM7808144","GSM7808023","GSM7808022","GSM7808143","GSM7808140","GSM7808039","GSM7808036","GSM7808157","GSM7808035","GSM7808156","GSM7808038","GSM7808159","GSM7808158","GSM7808037","GSM7808153","GSM7808032","GSM7808031","GSM7808152","GSM7808155","GSM7808034","GSM7808033","GSM7808154","GSM7808030","GSM7808151","GSM7808150","GSM7808047","GSM7808168","GSM7808167","GSM7808046","GSM7808049","GSM7808048","GSM7808169","GSM7808164","GSM7808043","GSM7808042","GSM7808163","GSM7808045","GSM7808166","GSM7808044","GSM7808165","GSM7808160","GSM7808041","GSM7808162","GSM7808161","GSM7808040","GSM7808058","GSM7808179","GSM7808057","GSM7808178","GSM7808059","GSM7808054","GSM7808175","GSM7808174","GSM7808053","GSM7808177","GSM7808056","GSM7808176","GSM7808055","GSM7808050","GSM7808171","GSM7808170","GSM7808173","GSM7808052","GSM7808051","GSM7808172","GSM7808180","GSM7808106","GSM7808105","GSM7808108","GSM7808107","GSM7808102","GSM7808069","GSM7808101","GSM7808068","GSM7808104","GSM7808103","GSM7808065","GSM7808064","GSM7808067","GSM7808100","GSM7808066","GSM7808061","GSM7808182","GSM7808181","GSM7808060","GSM7808184","GSM7808063","GSM7808062","GSM7808183","GSM7808070","GSM7808109","GSM7808117","GSM7808116","GSM7808119","GSM7808118","GSM7808113","GSM7808079","GSM7808112","GSM7808115","GSM7808114","GSM7808076","GSM7808075","GSM7808078","GSM7808111","GSM7808110","GSM7808077","GSM7808072","GSM7808071","GSM7808074","GSM7808073","GSM7808081","GSM7808080","GSM7808007","GSM7808128","GSM7808127","GSM7808006","GSM7808009","GSM7808129","GSM7808008","GSM7808124","GSM7808003","GSM7808002","GSM7808123","GSM7808126","GSM7808005","GSM7808004","GSM7808125","GSM7808087","GSM7808120","GSM7808086","GSM7808122","GSM7808089","GSM7808121","GSM7808088","GSM7808083","GSM7808082","GSM7808085","GSM7808084","GSM7808090","GSM7808092","GSM7808091"],"GPL":["571"],"GSE":["244163"],"taxon":["Homo sapiens"]}}