GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE244nnn/GSE244163/primaryOK200TranscriptomicsHomo sapiensExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE244163GEOGSEfalseMulti-platform genomic analysis of matched well- and dedifferentiated liposarcomas identify novel risk and progression determinantsTo define mechanisms that regulate biological behavior in well- and dedifferentiated liposarcoma (WD/DDLS) subsets, we describe an integrative analysis of DNA sequence, copy number and gene expression in 9 paired WDLS and DDLS samples with validation cohorts and in vitro studies. Amplification of 12q13-15 was common to all WDLS; 6q23-25 amplifications were observed 18% of WDLS and were associated with increased TAB2 and higher local recurrence risk versus non-6q-amplified WDLS. TAB2 knockdown decreased MDM2 protein expression and induced markers of cellular senescence in 6q23-25-amplified WDLS cells but not in non-amplified WDLS of amplified DDLS cells. Amplification of 6q23-25 was not associated with DDLS recurrence risk or progression from WDLS to DDLS. Instead, pathogenic ATRX mutations, recurrent losses in 13q and gains in 8q12-21 accompanied dedifferentiation. Downregulation of the 13q-encoded genes MYCBP2 and IRS2 was observed in DDLS versus WDLS; in vitro, these genes were essential for WDLS cell differentiation. Taken together, this study defines a copy number-driven model of liposarcoma initiation, progression, and differentiation.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 sapiens