{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE245nnn/GSE245857/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE245857"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Hepatic stellate cell-derived thrombospondin-2 as a novel therapeutic target for liver fibrosis","description":"The in vivo effects of silencing Thbs2 in hepatic stellate cells (HSCs) were examined using an adeno-associated virus vector (serotype 6, AAV6) containing short hairpin RNAs (shRNAs) targeting Thbs2, under the regulatory control of cytomegalovirus (CMV) or smooth muscle α-actin (αSMA) promoter, in carbon tetrachloride (CCl4) induced liver fibrosis mouse models. Bulk RNA-seq of liver tissues from AAV6-CMV-shThbs2 mice or AAV6-αSMA mice and their controls was performed.","dates":{"publication":"2026/04/01"},"accession":"GSE245857","cross_references":{"GSM":["GSM7849979","GSM7849977","GSM7849978","GSM7849976","GSM7849982","GSM7849983","GSM7849980","GSM7849981"],"GPL":["28330","17021"],"GSE":["245857"],"taxon":["Mus musculus"]}}