GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE245nnn/GSE245857/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE245857GEOGSEfalseHepatic stellate cell-derived thrombospondin-2 as a novel therapeutic target for liver fibrosisThe in vivo effects of silencing Thbs2 in hepatic stellate cells (HSCs) were examined using an adeno-associated virus vector (serotype 6, AAV6) containing short hairpin RNAs (shRNAs) targeting Thbs2, under the regulatory control of cytomegalovirus (CMV) or smooth muscle α-actin (αSMA) promoter, in carbon tetrachloride (CCl4) induced liver fibrosis mouse models. Bulk RNA-seq of liver tissues from AAV6-CMV-shThbs2 mice or AAV6-αSMA mice and their controls was performed.2026/04/01GSE245857GSM7849979GSM7849977GSM7849978GSM7849976GSM7849982GSM7849983GSM7849980GSM78499812833017021245857Mus musculus