GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE246nnn/GSE246303/primary200OKTranscriptomicsHomo sapiensExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE246303GEOGSEfalseTranscriptom modulated by LDOC1 / H2Bub1 axisMonoubiquitination of histone H2B on lysine 120 (H2Bub1) is one of the prominent epigenetic marks that regulates multiple cellular processes, including immunity, stem cell differentiation, tumorigenesis, and DNA damage response, mainly through affecting transcription of specific gene sets. The Ring Finger Protein 40 (RNF40) and its paralog RNF20 forms a stable E3 ligase heterodimer is the major enzymatic complex responsible for H2B monoubiquitylation. Dysregulation of H2Bub1 was observed in early stage of non-small cell lung carcinoma (NSCLC). However, the underlying regulatory mechanism and the impact of aberrant H2Bub1 level in the metastasis and chemotherapy response of NSCLC patients remains unelucidated. We found LDOC1 associated with RNF40 in NSCLC A549 cells. In this study, we investigate the role of LDOC1 in epigenome and aggressiveness of NSCLC involving H2Bub1.2026/06/30GSE246303GSM7866456GSM7866455GSM7866458GSM786645723159246303Homo sapiens