{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE247nnn/GSE247075/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE247075"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Activity-dependent expression of Fezf2 regulates inhibitory synapse formation","description":"The function of the cerebral cortex depends on the proper balance of excitation and inhibition within the cortical circuit. The amount of inhibition a given neuron receives is dependent on its neuronal type. Additionally, neurons can regulate the amount of inhibition they receive through activity-dependent regulation of gene expression. We use bulk sequencing of ribosome-associated RNA to show that selector gene Fezf2, which determines the specification of Layer 5 extratelencephalic (ET) projection neurons in utero, is regulated by neuronal activity. Postnatal reduction of Fezf2 expression decreases perisomatic inhibition originating from PV+ basket cells onto ET projection neurons, without affecting other hallmarks of ET neuron identity. We identify the type II Cadherin Cdh22 as a putative effector gene that is regulated both by FEZF2 and by neuronal activity, and removal of which decreases perisomatic inhibition.","dates":{"publication":"2026/09/14"},"accession":"GSE247075","cross_references":{"GSM":["GSM7882942","GSM7882946","GSM7882945","GSM7882944","GSM7882943","GSM7882947"],"GPL":["17021"],"GSE":["247075"],"taxon":["Mus musculus"]}}