{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE247nnn/GSE247372/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Drosophila melanogaster"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE247372"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Myc sustains Regional and Sexually Dimorphic Lipid Homeostasis in the Drosophila Intestine","description":"Organs are not uniform; distinct transcriptional and metabolic territories are apparent in key metabolic organs such as the intestine, liver or pancreas. Whether and why such organ zonation differs between the sexes remains to be explored, despite increasing interest in documenting and functionally interrogating sex differences in physiology. Here, we use the intestine of adult Drosophila to explore mechanisms of adult organ zonation. Through metabolic profiling, we uncover sex and regional differences in intestinal lipid metabolism. Cell type- and adult-specific genetic manipulations reveal a role for the Myc transcription factor in establishing sex-biased and regional intestinal lipid profiles. myc is repressed in male enterocytes by the sex determinant Doublesex, rendering Myc expression female-biased. Genetic gain- and loss-of-function experiments indicate that this Dsx-Myc antagonism in enterocytes underlies the sexually dimorphic and regional intestinal lipid profiles. The actions of Myc in gut enterocytes are physiologically significant: they extrinsically sustain female-biased lipid storage and fecundity. Our findings establish Myc as a new member of the sex differentiation pathway and a key regulator of organ zonation. They also underscore the need to consider the intestine as a previously unrecognised contributor to widely documented sex differences in lipid metabolism.","dates":{"publication":"2026/06/22"},"accession":"GSE247372","cross_references":{"GSM":["GSM7888000","GSM7888001","GSM7887999","GSM7887996","GSM7887995","GSM7887998","GSM7887997","GSM7888004","GSM7888005","GSM7887994","GSM7888002","GSM7888003"],"GPL":["17275"],"GSE":["247372"],"taxon":["Drosophila melanogaster"]}}