{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE252nnn/GSE252183/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus domesticus"," Mus musculus castaneus"," Mus musculus domesticus x Mus musculus castaneus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE252183"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A stem cell-derived neuronal culture model for mouse species variation in neurite growth","description":"Stem cell-derived neurons represent a powerful experimental system for the study of axon growth and regeneration, cutting cost and technical challenges. We developed an in vitro system using stem cell-derived motor neurons to investigate phenotypic differences in neurite growth between mouse subspecies. Previously, neurons in CAST/EiJ mice (Mus musculus castaneus) were reported to regrow CNS axons after injury to a greater degree than other strains. Here, we assayed neurite outgrowth from stem cell-neurons in a fully in vitro system, in the abscence of injury signals. In this system, CAST/EiJ neurons grew longer axons than those of C57BL/6J and 129S6/SvEv origin. Additionally, CASTx129 hybrid neurons exhibit comparable neurite growth to CAST/EiJ, indicating a dominant genetic effect.","dates":{"publication":"2026/04/06"},"accession":"GSE252183","cross_references":{"GSM":["GSM7474295","GSM7474294","GSM7996280","GSM7996281","GSM7996282","GSM7474299","GSM7474298","GSM7996283","GSM7996264","GSM7996265","GSM7474302","GSM7474301","GSM7474300","GSM7996270","GSM7996271","GSM7996272","GSM7996273","GSM7996274","GSM7996275","GSM7996276","GSM7996277","GSM7996256","GSM7996278","GSM7996279","GSM7996257","GSM7996258","GSM7996259"],"GPL":["33115","34045","29744"],"GSE":["252183"],"taxon":["Mus musculus domesticus"," Mus musculus castaneus"," Mus musculus domesticus x Mus musculus castaneus"]}}