GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE252nnn/GSE252183/primaryOK200TranscriptomicsMus musculus domesticus Mus musculus castaneus Mus musculus domesticus x Mus musculus castaneusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE252183GEOGSEfalseA stem cell-derived neuronal culture model for mouse species variation in neurite growthStem cell-derived neurons represent a powerful experimental system for the study of axon growth and regeneration, cutting cost and technical challenges. We developed an in vitro system using stem cell-derived motor neurons to investigate phenotypic differences in neurite growth between mouse subspecies. Previously, neurons in CAST/EiJ mice (Mus musculus castaneus) were reported to regrow CNS axons after injury to a greater degree than other strains. Here, we assayed neurite outgrowth from stem cell-neurons in a fully in vitro system, in the abscence of injury signals. In this system, CAST/EiJ neurons grew longer axons than those of C57BL/6J and 129S6/SvEv origin. Additionally, CASTx129 hybrid neurons exhibit comparable neurite growth to CAST/EiJ, indicating a dominant genetic effect.2026/04/06GSE252183GSM7474295GSM7474294GSM7996280GSM7996281GSM7996282GSM7474299GSM7474298GSM7996283GSM7996264GSM7996265GSM7474302GSM7474301GSM7474300GSM7996270GSM7996271GSM7996272GSM7996273GSM7996274GSM7996275GSM7996276GSM7996277GSM7996256GSM7996278GSM7996279GSM7996257GSM7996258GSM7996259331153404529744252183Mus musculus domesticus Mus musculus castaneus Mus musculus domesticus x Mus musculus castaneus