GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE254nnn/GSE254314/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE254314GEOGSEfalseDeficiency of m6A RNA methylation promotes ZBP1 mediated cell deathm6A RNA methylation suppresses the immunostimulatory potential of endogenous RNA. Deficiency of m6A provokes inflammatory responses and cell death, but the underlying mechanisms remain elusive. Here we showed that the noncoding RNA 7SK gains the immunostimulatory potential upon m6A depletion and subsequently activates RIG-I/MAVS axis to spark interferon (IFN) signaling cascades. Concomitant excess of IFN and m6A deficiency synergistically facilitate the formation of RNA G-quadruplexes (rG4) to promote ZBP1-mediated necroptotic cell death.2026/08/11GSE254314GSM8037597GSM8037598GSM8037595GSM8037596GSM8037593GSM8037594GSM8037591GSM8037592GSM8037605GSM8037603GSM8037604GSM8037601GSM8037602GSM8037599GSM8037600GSM803759021697254314Homo sapiens