GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE255nnn/GSE255483/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE255483GEOGSEfalseMultiple layers of innate immune response antagonism of SARS-CoV-2Analysis of immune cells in lungs from infected mice with either WT SARS-CoV-2, the NSP1 or the NSP15 mutant or mock-infection by single-cell RNA-seq identified 15 populations of major myeloid and lymphoid cells with changes in the pattern of their activation associated with viral infection. The effects of mutations in NSP1 or NSP15 on these responses suggested different immunosuppressive mechanisms of the two viral proteins.2026/06/03GSE255483GSM8073208GSM8073207GSM8073209GSM8073204GSM8073203GSM8073206GSM8073205GSM8073200GSM8073210GSM8073199GSM8073202GSM8073201GSM8073196GSM8073195GSM8073198GSM807319724247255483Mus musculus[42160380]