{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE256nnn/GSE256148/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE256148"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"IL-17 signaling pathway and NMDAR1 antibodies shape NMDAR encephalitis","description":"Human forebrain organoids (hFOs, day 110) derived from U2F iPS cell line were exposed with or without 10 μg/mL anti-NMDAR1 antibody for 24 hours. Organoids were then randomly selected for RNA sequencing (RNA-seq). By performing RNA-seq analysis, we showed that anti-NMDAR1 antibody exposure in hFOs downregulated expression of genes enriched with multiple neuronal functions including the glutamatergic synapse.These downregulated genes were also enriched with neuropsychiatric disorder-related genes.","dates":{"publication":"2026/04/08"},"accession":"GSE256148","cross_references":{"GSM":["GSM8086465","GSM8086466","GSM8086467","GSM8086468","GSM8086463","GSM8086464","GSM8086469"],"GPL":["29480"],"GSE":["256148"],"taxon":["Homo sapiens"],"PMID":["[41436585]"]}}