GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE256nnn/GSE256148/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE256148GEOGSEfalseIL-17 signaling pathway and NMDAR1 antibodies shape NMDAR encephalitisHuman forebrain organoids (hFOs, day 110) derived from U2F iPS cell line were exposed with or without 10 μg/mL anti-NMDAR1 antibody for 24 hours. Organoids were then randomly selected for RNA sequencing (RNA-seq). By performing RNA-seq analysis, we showed that anti-NMDAR1 antibody exposure in hFOs downregulated expression of genes enriched with multiple neuronal functions including the glutamatergic synapse.These downregulated genes were also enriched with neuropsychiatric disorder-related genes.2026/04/08GSE256148GSM8086465GSM8086466GSM8086467GSM8086468GSM8086463GSM8086464GSM808646929480256148Homo sapiens[41436585]