{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE261nnn/GSE261198/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE261198"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia","description":"To elucidate the role of STAT3β in acute myeloid leukemia (AML), we established a mouse model of STAT3β-deficient, MLL-AF9-driven AML. STAT3β-deficiency significantly shortened survival of leukemic mice confirming its role as a tumor suppressor. Furthermore, RNA sequencing revealed enhanced STAT1 expression and interferon (IFN) signaling upon loss of STAT3β.","dates":{"publication":"2024/06/03"},"accession":"GSE261198","cross_references":{"GSM":["GSM8137569","GSM8137568","GSM8137567","GSM8137573","GSM8137572","GSM8137571","GSM8137570","GSM8137566","GSM8137576","GSM8137565","GSM8137575","GSM8137574"],"GPL":["21103"],"GSE":["261198"],"taxon":["Mus musculus"],"PMID":["[38806478]"]}}