<HashMap><database>GEO</database><scores/><additional><omics_type>Transcriptomics</omics_type><species>Mus musculus</species><gds_type>Expression profiling by high throughput sequencing</gds_type><full_dataset_link>https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE261198</full_dataset_link><repository>GEO</repository><entry_type>GSE</entry_type></additional><is_claimable>false</is_claimable><name>A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia</name><description>To elucidate the role of STAT3β in acute myeloid leukemia (AML), we established a mouse model of STAT3β-deficient, MLL-AF9-driven AML. STAT3β-deficiency significantly shortened survival of leukemic mice confirming its role as a tumor suppressor. Furthermore, RNA sequencing revealed enhanced STAT1 expression and interferon (IFN) signaling upon loss of STAT3β.</description><dates><publication>2024/06/03</publication></dates><accession>GSE261198</accession><cross_references><GSM>GSM8137569</GSM><GSM>GSM8137568</GSM><GSM>GSM8137567</GSM><GSM>GSM8137573</GSM><GSM>GSM8137572</GSM><GSM>GSM8137571</GSM><GSM>GSM8137570</GSM><GSM>GSM8137566</GSM><GSM>GSM8137576</GSM><GSM>GSM8137565</GSM><GSM>GSM8137575</GSM><GSM>GSM8137574</GSM><GPL>21103</GPL><GSE>261198</GSE><taxon>Mus musculus</taxon><PMID>[38806478]</PMID></cross_references></HashMap>