{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE262nnn/GSE262435/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE262435"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Incorporation of genome-bound cellular proteins into HIV-1 particles regulates viral infection","description":"The initial steps of the human immunodeficiency virus 1 (HIV-1) lifecycle are regulated by cellular RNA-binding proteins (RBPs). To understand the scope of these early host-virus interactions, we developed in virion RNA interactome capture (ivRIC), which allowed the comprehensive and systematic profiling of the proteins that interact with the HIV-1 genomic (g)RNA inside viral particles. ivRIC identified 104 cellular RBPs within the encapsidated HIV-1 ribonucleoprotein, many of which are typically found in the cellular nucleus. Notably, these nuclear RBPs interact with the HIV-1 RBP Rev, suggesting that they associate with HIV-1 gRNA during its nuclear life. Functional assays show that ivRBPs are important for HIV-1, including PURA and PURB, which control viral gene expression and infectivity through interaction with critical sequences in the gRNA. Our characterisation of the composition of the encapsidated ribonucleoprotein of HIV-1 uncovers new host-virus interactions that invokes new mechanisms for controlling HIV-1 infection.","dates":{"publication":"2026/04/13"},"accession":"GSE262435","cross_references":{"GSM":["GSM8169663","GSM8169652","GSM8169664","GSM8169653","GSM8169661","GSM8169650","GSM8169662","GSM8169651","GSM8169660","GSM8169649","GSM8169658","GSM8169647","GSM8169659","GSM8169648","GSM8169645","GSM8169667","GSM8169656","GSM8169668","GSM8169657","GSM8169646","GSM8169665","GSM8169654","GSM8169666","GSM8169655"],"GPL":["21697"],"GSE":["262435"],"taxon":["Homo sapiens"],"PMID":["[41955099]"]}}