{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE262nnn/GSE262820/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Drosophila melanogaster"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE262820"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A nuclear role of tau in control DNA damage repair","description":"Neuronal protein tau has been implicated in the pathogenesis of Alzheimer's disease and related disorders termed as tauopathies. The tau proteins has been shown to primarily play a cytosolic role in the maintenence of actin and microtubules cytoskeleton but emerging evidence suggests a nuclear role of tau. In this study, we investigated a nuclear role of tau by doing scRNA-seq on the tau knock out Drosophila brains and subsequent in-vivo experiments to validate the findings. The results show tau protein to be a key modular of important nuclear signaling process such as DNA damage repair.","dates":{"publication":"2026/03/31"},"accession":"GSE262820","cross_references":{"GSM":["GSM8179944","GSM8179943","GSM8179945"],"GPL":["25244"],"GSE":["262820"],"taxon":["Drosophila melanogaster"]}}