GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE262nnn/GSE262820/primaryOK200TranscriptomicsDrosophila melanogasterExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE262820GEOGSEfalseA nuclear role of tau in control DNA damage repairNeuronal protein tau has been implicated in the pathogenesis of Alzheimer's disease and related disorders termed as tauopathies. The tau proteins has been shown to primarily play a cytosolic role in the maintenence of actin and microtubules cytoskeleton but emerging evidence suggests a nuclear role of tau. In this study, we investigated a nuclear role of tau by doing scRNA-seq on the tau knock out Drosophila brains and subsequent in-vivo experiments to validate the findings. The results show tau protein to be a key modular of important nuclear signaling process such as DNA damage repair.2026/03/31GSE262820GSM8179944GSM8179943GSM817994525244262820Drosophila melanogaster