{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE264nnn/GSE264747/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE264747"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"DC-SIGN+ Macrophages alleviates Non-Alcoholic Steatohepatitis by modulating inflammatory cytokine secretion","description":"The modulation of immune responses by innate immune receptors plays a pivotal role in the progression of non-alcoholic steatohepatitis (NASH). In this study, we aim to comprehensively dissect the involvement of the C-type lectin receptor DC-specific-ICAM3-grabbing-nonintegrin (DC-SIGN) in NASH progression. RNA sequencing was conducted on liver samples obtained from mice fed either a control diet or a HFHC diet inducing NASH for 16 weeks. At 8 weeks post feeding, animals were transduced via tail vein with Adeno-Associated Virus 9 (AAV9) expressing CD68 promoter-driven human DC-SIGN (hDC-SIGN) or GFP control. Data obtained from the transcriptomic profiles indicated that macrophage-specific delivery of hDC-SIGN strongly attenuated liver metabolic and inflammatory abnormalities, leading to the amelioration of NASH progression.","dates":{"publication":"2026/04/22"},"accession":"GSE264747","cross_references":{"GSM":["GSM8227145","GSM8227146","GSM8227143","GSM8227144","GSM8227149","GSM8227147","GSM8227148","GSM8227152","GSM8227141","GSM8227142","GSM8227150","GSM8227151","GSM8227140"],"GPL":["23479"],"GSE":["264747"],"taxon":["Mus musculus"],"PMID":["[41270396]"]}}