{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE266nnn/GSE266231/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE266231"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Female Mice with an Xist Deletion in B Cells Can Develop Lupus-Associated Phenotypes","description":"Systemic lupus erythematosus (SLE) is a female-biased autoimmune disease. X-Chromosome Inactivation (XCI) dosage compensates X-linked genes in females. Disrupted localization of Xist, a critical regulator of XCI, and aberrant expression of X-linked genes in female SLE patients and SLE mouse models suggest that XCI impairment contributes to disease. To test this, we conditionally deleted Xist in B cells (Xist cKO mice). Remarkably, some female Xist cKO mice spontaneously develop SLE phenotypes, including expansion of activated B cell subsets, development of disease-associated autoantibodies, and glomerulonephritis. Moreover, female Xist cKO mice with chemically induced SLE developed more activated B cells and dsDNA autoantibodies compared to treated wildtype female mice. Activated B cells from Xist cKO mice with SLE phenotypes have increased expression of X-linked immunity genes implicated in female-biased SLE. Our findings demonstrate that perturbations in B cell XCI maintenance directly contribute to female-biased SLE via upregulation of X-linked immunity-related genes.","dates":{"publication":"2026/05/15"},"accession":"GSE266231","cross_references":{"GSM":["GSM8242717","GSM8242718","GSM8242719","GSM8242713","GSM8242714","GSM8242715","GSM8242716","GSM8242720","GSM8242721","GSM8242722","GSM8242723","GSM8242706","GSM8242728","GSM8242729","GSM8242707","GSM8242708","GSM8242709","GSM8242724","GSM8242703","GSM8242725","GSM8242726","GSM8242704","GSM8242727","GSM8242705","GSM8242731","GSM8242732","GSM8242710","GSM8242733","GSM8242711","GSM8242734","GSM8242712","GSM8242730"],"GPL":["30172"],"GSE":["266231"],"taxon":["Mus musculus"]}}