{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE266nnn/GSE266417/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE266417"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Female Mice with an Xist Deletion in B Cells Can Develop Lupus-Associated Phenotypes","description":"Systemic lupus erythematosus (SLE) is a female-biased autoimmune disease. X-Chromosome Inactivation (XCI) dosage compensates X-linked genes in females. Disrupted localization of Xist, a critical regulator of XCI, and aberrant expression of X-linked genes in female SLE patients and SLE mouse models suggest that XCI impairment contributes to disease. To test this, we conditionally deleted Xist in B cells (Xist cKO mice). Remarkably, some female Xist cKO mice spontaneously develop SLE phenotypes, including expansion of activated B cell subsets, development of disease-associated autoantibodies, and glomerulonephritis. Moreover, female Xist cKO mice with chemically induced SLE developed more activated B cells and dsDNA autoantibodies compared to treated wildtype female mice. Activated B cells from Xist cKO mice with SLE phenotypes have increased expression of X-linked immunity genes implicated in female-biased SLE. Our findings demonstrate that perturbations in B cell XCI maintenance directly contribute to female-biased SLE via upregulation of X-linked immunity-related genes.","dates":{"publication":"2026/05/15"},"accession":"GSE266417","cross_references":{"GSM":["GSM8246649","GSM8246669","GSM8246647","GSM8246648","GSM8246667","GSM8246645","GSM8246668","GSM8246646","GSM8246665","GSM8246666","GSM8246644","GSM8246663","GSM8246664","GSM8246661","GSM8246662","GSM8246660","GSM8246658","GSM8246659","GSM8246656","GSM8246657","GSM8246654","GSM8246655","GSM8246652","GSM8246653","GSM8246650","GSM8246651","GSM8246670","GSM8246671"],"GPL":["30172"],"GSE":["266417"],"taxon":["Mus musculus"]}}