{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE267nnn/GSE267409/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Homo sapiens"],"gds_type":["Methylation profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE267409"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"TET2 affects keratinocytes and psoriatic dermatitis by regulating MECOM and NTRK1 hydroxymethylation","description":"The ten-eleven translocation (TET) family dioxygenases TET2 oxidize 5-methylcytosine (5-mC) to 5-hmC in DNA. DNA hydroxymethylation is the most crucial epigenetic modifications in the occurrence and development of a variety of skin diseases. The goal is to determine the targets of TET2 knockdown including DNA hydroxymethylation in keratinocytes. We profiled a number of important signaling pathways and key factors that may be associated with psoriasis hydroxymethylation and may be potential biomarkers for psoriasis.","dates":{"publication":"2026/06/01"},"accession":"GSE267409","cross_references":{"GSM":["GSM8265313","GSM8265312","GSM8265315","GSM8265314"],"GPL":["13497"],"GSE":["267409"],"taxon":["Homo sapiens"]}}