{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE268nnn/GSE268194/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE268194"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Identification of the RNA that binds with FAK by high-throughput RIP-seq in MDA-MB-231 cells","description":"FAK is overexpressed and aberrantly activated in various advanced solid tumors and plays a critical role in tumor progression and metastasis. Here, we identified an FAK-interacting lncRNA FAISL, FAISL (FAK Interacting and Stabilizing LncRNA) was frequently overexpressed in TNBC tissues and abundantly enriched in FAK-interacting lncRNAs. FAISL promotes cell adhesion, cytoskeleton spreading, proliferation and anchor-dependent survival of TNBC cells. FAISL doesn’t affect FAK mRNA but positively regulates the FAK protein level by blocking Calpain 2-mediated proteolysis, etc.","dates":{"publication":"2026/05/01"},"accession":"GSE268194","cross_references":{"GSM":["GSM8287593","GSM8287592","GSM8287591"],"GPL":["24676"],"GSE":["268194"],"taxon":["Homo sapiens"]}}